Dance punk and electronic beats will fill the East End as Major Lazer and LCD Soundsystem headline Lovebox 2016.
LCD will take to the stage at Victoria Park for the first time since their action-packed gig at New York’s Madison Square Gardens in 2011, after which they took a five-year break from the music scene.
The New York band will have a back-catalogue spanning a decade to draw upon for the show on Saturday, July 16.
The wistful, alt-disco tunes on the summer setlist are sure to feature hits Daft Punk Is Playing At My House and All My Friends as well as new material set to be released later this year.
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Member James Murphy said on their website: “It’s the bus full of substitute teachers back from their coffee break with new music and the same weird gear.”
Before the Americans make their mark on the East End, the two-day festival will kick off with Major Lazer.
The conceptual electronic act - founded by producer Diplo and fronted by a cartoon character - will headline on the main stage on Friday, July 15.
Last year, the band famed for mixing up everything from reggae and dance hall to electronica and house released third album, Peace Is The Mission.
Lead single Lean On became a global phenomenon with the video clocking up one billion views.
They will follow it up with Music Is The Weapon, due out in later this year.
Meanwhile Lovebox organisers promise what they call “an unforgettable, unmissable show that will be a defining moment of festival season.”
A statement added: “When this euphoric, colourful carnival rolls into London to headline the Lovebox Main Stage on the Friday, there will be fireworks – both literal and metaphorical.”