A proposal for 900 apartments in the heart of the Isle of Dogs is to be decided on by Tower Hamlets Council on Thursday.
2 Millharbour, a residential-led, mixed scheme, will rise to 42 storeys if approved.
Council officers have recommended it for approval but there will be a number of speakers against the plans concerned about over-development of the area.
Applicant GDL Limited wants to develop on the former business park. The scheme would see 624 homes available on the open market, 157 affordable rent apartments and 120 intermediate.
A total of 104 of properties would have three bedrooms.
During consultation process 35 people objected to the plans. Opposition included concerns over the disruption to the Canary Wharf skyline and a lack of public amenities in the surrounding area to cater for the increase in residents.
Another objection was the South Quay Masterplan was in development and the proposal should be held until it was completed.
However, planning officer Nasser Farooq said the density would "not result in significantly adverse impacts typically associated with overdevelopment".
He added: "The scale and form of the proposed tall buildings would successfully mediate between Canary Wharf and existing/consented buildings to the south of Marsh Wall.
"They would be of high quality design, provide a positive contribution to the skyline and not adversely impact on heritage assets or strategic or local views."
The site has been earmarked for redevelopment for over a decade with a planning application approved in 2003.