The tallest residential building in the UK will rise 220m above South Quay now that it has cleared the final hurdle.

Mayor of London Boris Johnson has told Tower Hamlets Council that he would not call in the scheme which means final approval can now be given. Previously he had expressed concern over the level of developments on South Quay.

Berkeley Homes will develop a 68-storey and 36-storey building based on designs by Foster + Partners at 183-189 Marsh Wall. Originally the height was set at 73 storeys but was reduced over density and safety fears.

In total, 888 homes are planned in all, including 188 affordable properties. Construction is expected to start in July 2016, lasting five years in a number of phases.

The plans were initially approved in November last year despite protests from Canary Wharf councillor Andrew Woods who has been campaigning for a more strategic view of South Quay.

He found support with Mr Johnson who expressed a fear in October that “too many tall buildings are being proposed without an overall vision for the area”. The mayor said he would work with Tower Hamlets Borough Council to assist with the strategy.

Sir Edward Lister, deputy mayor for planning said at the time: “South Quay is enjoying unprecedented interest from developers all of whom want to bring forward their own plans.

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“While we want to see the comprehensive regeneration of the area, what we cannot allow is a situation where planning is granted on a first-come-first-served basis with no overall strategy, as this could eat up valuable space, have a negative impact on the public realm and potentially cause other schemes to collapse.”

Berkeley is making a £7million contribution to the public purse.

At the time of the initial approval, Isle of Dogs resident Sarah Castro told the committee she was concerned for children living in the proposed towers.

“227 children will be living there and the leisure space is the size of a postage stamp,” she said. “I’ve raised children in a tall building and it’s extremely stressful.

“We need to get developers to raise their game and build developments that will enhance communities.”

Berkeley’s Harry Lewis defended the scheme from criticisms of overdevelopment. “Over half of the site will be given over to public realm,” he said.

South Quay Plaza as envisioned by developer Berkeley