Coast Guard Cutter Eagle, known as America’s Tall Ship, is due to open to to the public after dropping anchor at Canary Wharf.
The US vessel has sailed up the Thames and will open up for public tours during its stay.
At 90m in length, Eagle has served as a classroom at sea to future coast guard officers since 1946.
It was constructed in 1936 by the Blohm and Voss Shipyard in Hamburg, Germany and was originally commissioned as Horst Wesell by the German Navy.
The ship is a three-masted barque with more than 6,797sqm of sail and 9.7km of rigging.
America received Eagle as part of the reparations following the Second World War.
During this voyage, she has hosted cadets from the Royal Malaysian and Honduran navies.
After departing London, the vessel will set her course for Madeira, Portugal, following the same route it charted when first coming to the United States 80 years ago.
Eagle will be open for free public tours from Thursday, June 9 to Monday, June 13.
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